If a dialogue is established upon receipt of a promotional email, is there a requirement to provide both prescribing information and an unsubscribe option with each email response?

Yes. The provision of prescribing information would depend on the content of the enquiry and the response. Where the prescribing information is required on the original email then reference to its availability at the bottom of the email chain and/or a hyperlink to that part of the email should be provided with each response in that email chain, irrespective of the content of the response. It might be better in certain circumstances to start a new standalone email. The requirement to unsubscribe is required on all promotional emails.

Clauses 12.1 and 15.5 provide further information